翻訳と辞書 Words near each other ・ Homogeneous tree ・ Homogeneous variety ・ Homogeneously staining region ・ Homogeneously Suslin set ・ Homogenes ・ Homogenes albolineatus ・ Homogenes leprieurii ・ Homogenes mimus ・ Homogenes rubrogaster ・ Homogenic ・ Homogenic Tour ・ Homogenization (biology) ・ Homogenization (chemistry) ・ Homogenization (climate) ・ Homogenizer ・ Homogentisate 1,2-dioxygenase ・ Homogentisic acid ・ Homoglaea ・ Homoglutathione synthase ・ Homoglyph ・ Homograph ・ Homography ・ Homography (computer vision) ・ Homography (disambiguation) ・ Homogyna ・ Homogyna alluaudi ・ Homogyna bartschi ・ Homogyna endopyra ・ Homogyna ignivittata ・ Homogyna pygmaea Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Homogentisate 1,2-dioxygenase ： ウィキペディア英語版 Homogentisate 1,2-dioxygenase Homogentisate 1,2-dioxygenase (homogentisic acid oxidase, homogentisicase) is an enzyme, which catalyzes the conversion of homogentisate to 4-maleylacetoacetate. Homogentisate 1,2-dioxygenase or HGD is involved in the catabolism of aromatic rings, more specifically in the breakdown of the amino acids tyrosine and phenylalanine. HGD appears in the metabolic pathway of tyrosine and phenylalanine degradation once the molecule homogentisate is produced. Homogentisate reacts with HGD to produce maleylacetoacetate, which then is further used in the metabolic pathway. HGD requires the use of Fe2+ and O2 in order to cleave the aromatic ring of homogentisate. Image:Homogentisic acid.svg|homogentisate Image:4-maleylacetoacetic acid.svg|4-maleylacetoacetate ==Enzyme Active Site== The active site of Homogentisate 1,2-dioxygenase was determined through the crystal structure, which was captured through the work of Titus et al.〔 Through the crystal structure the active site was found to contain the following residues; His292, His335, His365, His371, and Glu341. Homogentisate binds in the active site to Glu341, His335, and His371 via the Fe2+ atom. The His292 binds to the hydroxyl group of the aromatic ring. His365 binds to Glu341 via hydrogen bonding to stabilize the amino acid side chains. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Homogentisate 1,2-dioxygenase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.